PRL-8-53 is really a nootropic research chemical produced from benzoic acidity and phenylmethylamine (Benzylamine) that’s been proven to do something like a hypermnesic drug in humans it was initially synthesized by medical chemistry professor Nikolaus Hansl at Creighton College within the 1970s within his focus on amino ethyl meta benzoic acidity esters.
PRL-8-53 isn’t a treatment for disease or illness, although a nootropic effect in healthy individuals continues to be claimed. Just one study in humans was reported in 1978. The double-blind trial of PRL-8-53 in 47 healthy volunteers measured its effects on a number of cognitive measures. 5 mg from the drug was administered orally 2-2.5 hrs prior to the study tasks. Overall enhancements in recollection differed according to the number of words were remembered under placebo, using the poor performers (six words or less) experiencing an 87.5-105% rise in recollection and also the high performers (eight or even more words) a 7.9-14% increase which unsuccessful to achieve record significance when controlling for subjects older than 30 only, a 108-152% increase was noted. They noted this was likely a direct result a ceiling effect because of a lot of their subjects scoring near to 100% around the recall test even on placebo. No negative effects were reported throughout the trial.
The precise mechanism of action of PRL-8-53 remains unknown. Doses as much as 200 mg/kg aren’t observed to possess stimulant qualities, along with a dosage of 20 mg/kg doesn’t potentiate the results of dextroamphetamine in rats. It displays possible cholinergic qualities, and potentiates dopamine while partly inhibiting serotonin. PRL-8-53 reverses the catatonic and ptotic results of reserpine.
PRL-8-53 is comparatively non-toxic, by having an dental LD50 in rodents of 860 mg/kg, giving the drug a higher therapeutic index. Doses above 8 mg/kg have brief hypotensive effects within the canine. High doses depress motor activity within the rat and mouse, using the ED50 for any 50% decrease in motor activity of rodents at 160 mg/kg. PRL-8-53 displays spasmolytic effects.
Methyl 3-(2-(benzylmethylamino)ethyl)benzoate hydrochloride
3-(2-benzylmethylaminoethyl) benzoic acidity methyl ester hydrochloride
3-(2-(Methyl(phenylmethyl)amino)ethyl)benzoic acidity methyl ester hydrochloride